Lalistat 1 | Tocris Bioscience 6098/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Lalistat 1

catalog :

6098/10

quantity :

10 mg (also 50 mg)

price :

254 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Cui W, Sathyanarayan A, Lopresti M, Aghajan M, Chen C, Mashek D. Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Autophagy. 2020;:1-16 pubmed publisher
Schott M, Weller S, Schulze R, Krueger E, Drizyte Miller K, Casey C, et al. Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes. J Cell Biol. 2019;218:3320-3335 pubmed publisher
Wu H, Ploeger J, Kamarajugadda S, Mashek D, Mashek M, Manivel J, et al. Evidence for a Novel Regulatory Interaction Involving Cyclin D1, Lipid Droplets, Lipolysis, and Cell Cycle Progression in Hepatocytes. Hepatol Commun. 2019;3:406-422 pubmed publisher

product information

brand :

Tocris

catalog number base :

6098

SKU :

6098/10

product name :

Lalistat 1

units size :

10 mg (also 50 mg)

description :

Potent and selective LAL inhibitor

target :

Lysosomal Acid Lipase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

298.36

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 M concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.

top caption :

Potent and selective LAL inhibitor

extended description :

Potent and selective LAL inhibitor

chemical name text :

4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate

formula :

C12H18N4O3S

formula text :

C12H18N4O3S

cas num :

501104-16-1

USD :

254 USD

product details :

Potent and selective LAL inhibitor

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage