Perifosine | Tocris Bioscience 6087 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Perifosine

catalog :

6087

quantity :

10 mg (also 50 mg)

price :

102 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Fu L, Kim Y, Wang X, Wu X, Yue P, Lonial S, et al. Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 2009;69:8967-76 pubmed publisher

product information

brand :

Tocris

master code :

6087

SKU :

6087/10

product name :

Perifosine

description :

PKB/Akt inhibitor; also modulates Kv2.1 current

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

461.66

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

catalog number base :

6087

product keywords :

PKB Akt inhibitors inhibts lipid rafts MAPK autophagy apoptosis induces inducers Kv2.1 antitumor orally bioavailable inward rectifier potassium current KRX-0401 Akt (Protein Kinase B) Protein Kinase B/Akt Autophagy Voltage-Gated Potassium Channels 6087,

extended description :

PKB/Akt inhibitor; also modulates Kv2.1 current

chemical name text :

Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate

formula :

C 25 H 52 NO 4 P

formula text :

C25H52NO4P

cas num :

157716-52-4

2020 USD :

2021 USD :

102 USD

alt names :

KRX-0401

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage