Perifosine | Tocris Bioscience 6087/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Perifosine

catalog :

6087/10

quantity :

10 mg (also 50 mg)

price :

119 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Fu L, Kim Y, Wang X, Wu X, Yue P, Lonial S, et al. Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 2009;69:8967-76 pubmed publisher

product information

brand :

Tocris

master code :

6087

SKU :

6087/10

rank :

0.0007

product name :

Perifosine

description :

PKB/Akt inhibitor; also modulates Kv2.1 current

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

extended description :

PKB/Akt inhibitor; also modulates Kv2.1 current

chemical name text :

Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate

formula :

C 25 H 52 NO 4 P

formula text :

C25H52NO4P

cas num :

157716-52-4

USD :

119 USD

product details :

PKB/Akt inhibitor; also modulates Kv2.1 current

alt names :

KRX-0401

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage