Perifosine | Tocris Bioscience 6087/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Perifosine

catalog :

6087/10

quantity :

10 mg (also 50 mg)

price :

130 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Nanou A, Bourbouli M, Vetrano S, Schaeper U, Ley S, Kollias G. Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis. Cell Rep. 2021;35:109168 pubmed publisher
Fu L, Kim Y, Wang X, Wu X, Yue P, Lonial S, et al. Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 2009;69:8967-76 pubmed publisher

product information

brand :

Tocris

catalog number base :

6087

SKU :

6087/10

product name :

Perifosine

units size :

10 mg (also 50 mg)

description :

PKB/Akt inhibitor; also modulates Kv2.1 current

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

461.66

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

top caption :

PKB/Akt inhibitor; also modulates Kv2.1 current

extended description :

PKB/Akt inhibitor; also modulates Kv2.1 current

chemical name text :

Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate

formula :

C25H52NO4P

formula text :

C25H52NO4P

cas num :

157716-52-4

USD :

130 USD

product details :

PKB/Akt inhibitor; also modulates Kv2.1 current

alt names :

KRX-0401

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage