Ani 9 | Tocris Bioscience 6076/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ani 9

catalog :

6076/10

quantity :

10 mg (also 50 mg)

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Dwivedi R, Drumm B, Alkawadri T, Martin S, Sergeant G, Hollywood M, et al. The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells. Eur J Pharmacol. 2023;947:175677 pubmed publisher
Filippou A, Pehkonen H, Karhemo P, V xe4 xe4 n xe4 nen J, Nieminen A, Klefstr xf6 m J, et al. ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2021;13: pubmed publisher

product information

brand :

Tocris

catalog number base :

6076

SKU :

6076/10

product name :

Ani 9

units size :

10 mg (also 50 mg)

description :

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

target :

Calcium-activated Chloride Channel Blockers

category :

Small Molecules

purity :

98%

observed molecular weight :

332.78

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ani 9 is a potent and selective TMEM16A (Anoctamin-1; ANO1) blocker (IC50 = 77 nM). Displays no effect on ANO2 activity (at 10 M). Also exhibits no effect on intracellular calcium signaling or CFTR and ENaC channel activity (at 30 M).

top caption :

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

extended description :

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

chemical name text :

2-(4-Chloro-2-methylphenoxy)-N -(2-methoxybenzylidene)acetohydrazide

formula :

C17H17ClN2O3

formula text :

C17H17ClN2O3

cas num :

356102-14-2

USD :

238 USD

product details :

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage