Nutlin 3a | Tocris Bioscience 6075/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Nutlin 3a

catalog :

6075/5

quantity :

5 mg (also 25 mg)

price :

276 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Jung J, Liao H, Coker S, Liang H, Hancock J, Denicourt C, et al. p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of MCOLN1. iScience. 2021;24:102701 pubmed publisher
Ying Z, Beronja S. Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers. Cell Stem Cell. 2020;26:403-419.e4 pubmed publisher

image

image 1 :

Cat.No. 6075 - Nutlin 3a C30H30Cl2N4O4 CAS No. 675576-98-4

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6075

SKU :

6075/5

product name :

Nutlin 3a

description :

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

target :

Ubiquitin Ligase (E3) Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

97%

storage :

Store at -20°C

observed molecular weight :

581.49

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Nutlin 3a is an MDM2 antagonist (IC50 = 90 nM); inhibits the MDM2-p53 interaction. Active enantiomer of Nutlin-3 (Cat. No. 3984). Induces expression for P53 regulated genes. Suppresses tumor growth in vivo 98% in prostate cancer and osteosarcoma cancer models. Antiproliferative.

product keywords :

Nutlin3a p53 activators MDM2 antagonism antagonists p53-MDM2 activates Ubiquitin E3 Ligases p53 6075, E3 Ligase

extended description :

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

chemical name text :

4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

formula :

C30H30Cl2N4O4

formula text :

C30H30Cl2N4O4

cas num :

675576-98-4

USD :

264

USD 2025 :

276 USD

product details :

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

more info or order :

Tocris Bioscience product webpage