Pladienolide B | Tocris Bioscience 6070 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pladienolide B

catalog :

6070

quantity :

500 ug

price :

371 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Crews L, Balaian L, Delos Santos N, Leu H, Court A, Lazzari E, et al. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016;19:599-612 pubmed publisher
Pederiva C, BÃ¶hm S, Julner A, Farnebo M. Splicing controls the ubiquitin response during DNA double-strand break repair. Cell Death Differ. 2016;23:1648-57 pubmed publisher
Salton M, Misteli T. Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy. Trends Mol Med. 2016;22:28-37 pubmed publisher
Disney M. Short-circuiting RNA splicing. Nat Chem Biol. 2008;4:723-4 pubmed publisher
Kotake Y, Sagane K, Owa T, Mimori Kiyosue Y, Shimizu H, Uesugi M, et al. Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol. 2007;3:570-5 pubmed

product information

brand :

Tocris

master code :

6070

SKU :

6070/500U

product name :

Pladienolide B

description :

mRNA splicing inhibitor; antitumor

target :

DNA, RNA and Protein Synthesis Inhibitors

category :

Small Molecules

unit size :

500 ug

purity :

95%

observed molecular weight :

536.7

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

mRNA splicing inhibitor; decreases splicing capacity up to 75% in vitro . Directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Arrests cell cycle in G1 and G2/M phases. Displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM). Cell permeable and active in vivo .

catalog number base :

6070

product keywords :

mRNA splicing inhibitors inhibits splicesome-associated 130 SAP130 splicing factor 3B subunit SF3B1 U2 small nuclear ribonucleoprotein U2 snRNP cell cycle antitumor anticancer cell permeable active in vivo DNA, RNA and Protein Synthesis Cell Cycle Inhibitors 6070,

extended description :

mRNA splicing inhibitor; antitumor

chemical name text :

(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one

formula :

C 30 H 48 O 8

formula text :

C30H48O8

cas num :

445493-23-2

2020 USD :

363

2021 USD :

371 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage