Pladienolide B | Tocris Bioscience 6070/500U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pladienolide B

catalog :

6070/500U

quantity :

500 ug

price :

430 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Crews L, Balaian L, Delos Santos N, Leu H, Court A, Lazzari E, et al. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016;19:599-612 pubmed publisher
Pederiva C, BÃ¶hm S, Julner A, Farnebo M. Splicing controls the ubiquitin response during DNA double-strand break repair. Cell Death Differ. 2016;23:1648-57 pubmed publisher
Salton M, Misteli T. Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy. Trends Mol Med. 2016;22:28-37 pubmed publisher
Disney M. Short-circuiting RNA splicing. Nat Chem Biol. 2008;4:723-4 pubmed publisher
Kotake Y, Sagane K, Owa T, Mimori Kiyosue Y, Shimizu H, Uesugi M, et al. Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol. 2007;3:570-5 pubmed

product information

brand :

Tocris

master code :

6070

SKU :

6070/500U

rank :

0.0007

product name :

Pladienolide B

description :

mRNA splicing inhibitor; antitumor

target :

DNA, RNA and Protein Synthesis Inhibitors

category :

Small Molecules

sizes available :

500 ug

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pladienolide B is a mRNA splicing inhibitor that decreases splicing capacity up to 75% in vitro . Pladienolide B directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Pladienolide B arrests the cell cycle in G1 and G2/M phases and displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM). Cell permeable and active in vivo .

extended description :

mRNA splicing inhibitor; antitumor

chemical name text :

(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one

formula :

C 30 H 48 O 8

formula text :

C30H48O8

cas num :

445493-23-2

USD :

430 USD

product details :

mRNA splicing inhibitor; antitumor

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage