Pladienolide B | Tocris Bioscience 6070/500U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pladienolide B

catalog :

6070/500U

quantity :

500 ug

price :

481 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Li S, Yang M, Shen H, Ding L, Lyu X, Lin K, et al. Capturing totipotency in human cells through spliceosomal repression. Cell. 2024;187:3284-3302.e23 pubmed publisher
Zhang P, Zhai X, Huang B, Sun S, Wang W, Zhang M. Highly efficient generation of blastocyst-like structures from spliceosomes-repressed mouse totipotent blastomere-like cells. Sci China Life Sci. 2023;66:423-435 pubmed publisher
Taubenschmid Stowers J, Rostovskaya M, Santos F, Ljung S, Argelaguet R, Krueger F, et al. 8C-like cells capture the human zygotic genome activation program in vitro. Cell Stem Cell. 2022;29:449-459.e6 pubmed publisher
Chang A, Zhou Y, Iyengar S, Pobiarzyn P, Tishchenko P, Shah K, et al. Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response. J Biol Chem. 2021;297:101277 pubmed publisher
Lu S, De Neef E, Thomas J, SABIO E, Rousseau B, Gigoux M, et al. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell. 2021;184:4032-4047.e31 pubmed publisher
Matos D, Zhang J, Ouyang J, Nguyen H, Genois M, Zou L. ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop. Mol Cell. 2020;77:514-527.e4 pubmed publisher
Crews L, Balaian L, Delos Santos N, Leu H, Court A, Lazzari E, et al. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016;19:599-612 pubmed publisher
Pederiva C, BÃ¶hm S, Julner A, Farnebo M. Splicing controls the ubiquitin response during DNA double-strand break repair. Cell Death Differ. 2016;23:1648-57 pubmed publisher
Salton M, Misteli T. Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy. Trends Mol Med. 2016;22:28-37 pubmed publisher
Disney M. Short-circuiting RNA splicing. Nat Chem Biol. 2008;4:723-4 pubmed publisher
Kotake Y, Sagane K, Owa T, Mimori Kiyosue Y, Shimizu H, Uesugi M, et al. Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol. 2007;3:570-5 pubmed

product information

brand :

Tocris

catalog number base :

6070

SKU :

6070/500U

product name :

Pladienolide B

units size :

500 ug

description :

mRNA splicing inhibitor; antitumor

target :

DNA, RNA and Protein Synthesis Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

536.7

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pladienolide B is a mRNA splicing inhibitor that decreases splicing capacity up to 75% in vitro . Pladienolide B directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Pladienolide B arrests the cell cycle in G1 and G2/M phases and displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM). Transient treatment with pladienolide B can reprogram pluripotent hESCs into a distinct type of zigotic genome activation (ZGA)-like cells (ZLCs). Cell permeable and active in vivo .

top caption :

mRNA splicing inhibitor; antitumor

extended description :

mRNA splicing inhibitor; antitumor

chemical name text :

(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one

formula :

C30H48O8

formula text :

C30H48O8

cas num :

445493-23-2

USD :

481 USD

product details :

mRNA splicing inhibitor; antitumor

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage