chemical

Lin28 1632

6068

10 mg (also 50 mg)

174 USD

6068

6068/10

Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

DNA, RNA and Protein Synthesis Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

281.31

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

RNA binding protein Lin28 inhibitor (IC50 = 8 M). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Inhibits growth of tumor cell lines and tumor-sphere formation in vitro . Also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity . Also bromodomain inhibitor.

6068

Lin281632 RNA-binding protein Lin28 stem cell differentiation bromodomains inhibitors inhibits PD-L1 let-7 antitumor immunity Bromodomains DNA, RNA and Protein Synthesis ESCs and iPSC Immune Checkpoints 6068,

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

C 15 H 15 N 5 O

C15H15N5O

108825-65-6

167

174 USD

Store at +4°C