chemical

Lin28 1632

6068/10

10 mg (also 50 mg)

202 USD

6068

6068/10

0.0006

Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

DNA, RNA and Protein Synthesis Inhibitors

Small Molecules

10 mg (also 50 mg)

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Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 M). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro . Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity . Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

C 15 H 15 N 5 O

C15H15N5O

108825-65-6

202 USD

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Store the unopened product at 2 - 8 °C. Do not use past expiration date.