AZD 2461 | Tocris Bioscience 6060 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZD 2461

catalog :

6060

quantity :

10 mg (also 50 mg)

price :

107 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6060

SKU :

6060/10

product name :

AZD 2461

description :

Potent PARP inhibitor; orally bioavailable

target :

Poly(ADP-ribose) Polymerase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

395.43

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent PARP inhibitor (IC50 values are 2, 5 and 200 nM for PARP2, PARP1 and PARP3, respectively). Exhibits anticancer effects in BRCA1 mutant, but not wild-type breast cancer cell lines in vitro . Inhibits growth of olaparib-resistant mammary tumors in a mouse model and is a poor substrate for the P-gp transporter. Orally bioavailable.

catalog number base :

6060

product keywords :

AZD2461 potent PARP inhibitors inhibits poly (ADP-ribose) polymerases orally bioavailable chemotherapeutics Poly(ADP-ribose) Polymerase 6060,

extended description :

Potent PARP inhibitor; orally bioavailable

chemical name text :

4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone

formula :

C 22 H 22 FN 3 O 3

formula text :

C22H22FN3O3

cas num :

1174043-16-3

2020 USD :

118

2021 USD :

107 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage