LDN 193189 dihydrochloride | Tocris Bioscience 6053 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LDN 193189 dihydrochloride

catalog :

6053

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Xiang C, Du Y, Meng G, Soon Yi L, Sun S, Song N, et al. Long-term functional maintenance of primary human hepatocytes in vitro. Science. 2019;364:399-402 pubmed publisher
Genga R, Kernfeld E, Parsi K, Parsons T, Ziller M, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. Cell Rep. 2019;27:708-718.e10 pubmed publisher
Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, et al. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2018;23:123-131.e6 pubmed publisher
Beraldo F, Ostapchenko V, Xu J, Di Guglielmo G, Fan J, Nicholls P, et al. Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex. J Neurochem. 2018;145:68-79 pubmed publisher
Alsanie W, Niclis J, Hunt C, De Luzy I, Penna V, Bye C, et al. Specification of murine ground state pluripotent stem cells to regional neuronal populations. Sci Rep. 2017;7:16001 pubmed publisher
Young F, Keruzore M, Nan X, Gennet N, Bellefroid E, Li M. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. Proc Natl Acad Sci U S A. 2017;114:E5599-E5607 pubmed publisher

product information

brand :

Tocris

master code :

6053

SKU :

6053/10

product name :

LDN 193189 dihydrochloride

description :

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

target :

BMP and Other Activin Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

479.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits 200-fold selectivity for BMP signaling over TGF- signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No. 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No. 4423) and DAPT (Cat.No. 2634).

catalog number base :

6053

product keywords :

LDN193189 dihydrochloride BMP signaling ALK2 ALK3 activin bone morphogenetic proteins stem cells neural differentiation neurons BMP and Other Activin Receptors ESCs and iPSC Neural Stem Cells Organoids 6053,

extended description :

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

chemical name text :

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride

formula :

C 25 H 22 N 6 .2HCl

formula text :

C25H22N6.2HCl

cas num :

1435934-00-1

2020 USD :

205

2021 USD :

216 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage