product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
G 5555
catalog :
6051
quantity :
50 mg
price :
711 USD
more info or order :
Tocris Bioscience product webpage
product information
brand :
Tocris
master code :
6051
SKU :
6051/50
product name :
G 5555
description :
High affinity group I PAK inhibitor
target :
PAK Inhibitors
category :
Small Molecules
unit size :
50 mg
purity :
98%
observed molecular weight :
492.96
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
High affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (Ki = 3.7 nM; pMEK IC50 = 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited 70%. Exhibits low hERG channel activity ( 50% inhibition at 10 M). Orally bioavailable.
catalog number base :
6051
product keywords :
G5555 Selective high affinity group 1 PAK pan-PAK1 PAK2 PAK3 inhibitors inhibits orally bioavailable p21 activated kinase P21-activated Kinases 6051, p21-Activated Kinases, p21-Activated Kinase, PAKs
extended description :
High affinity group I PAK inhibitor
chemical name text :
8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one
formula :
C 25 H 25C lN 6 O 3
formula text :
C25H25ClN6O3
cas num :
1648863-90-4
2020 USD :
690
2021 USD :
711 USD
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK