G 5555 | Tocris Bioscience 6051/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

G 5555

catalog :

6051/10

quantity :

10 mg (also 50 mg)

price :

189 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Brown T, Hashimoto H, Finseth L, Wood T, Macklin W. PAK1 positively regulates oligodendrocyte morphology and myelination. J Neurosci. 2021;: pubmed publisher

image

image 1 :

Cat.No. 6051 - G 5555 C25H25ClN6O3 CAS No. 1648863-90-4

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6051

SKU :

6051/10

product name :

G 5555

description :

High affinity group I PAK inhibitor

target :

PAK Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

492.96

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

G 5555 is a high affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (Ki = 3.7 nM; pMEK IC50 = 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited 70%. Exhibits low hERG channel activity ( 50% inhibition at 10 M). Orally bioavailable.

product keywords :

G5555 Selective high affinity group 1 PAK pan-PAK1 PAK2 PAK3 inhibitors inhibits orally bioavailable p21 activated kinase P21-activated Kinases 6051, p21-Activated Kinases, p21-Activated Kinase, PAKs

extended description :

High affinity group I PAK inhibitor

chemical name text :

8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one

formula :

C25H25ClN6O3

formula text :

C25H25ClN6O3

cas num :

1648863-90-4

USD :

210

USD 2025 :

189 USD

product details :

High affinity group I PAK inhibitor

more info or order :

Tocris Bioscience product webpage