LM22B 10 | Tocris Bioscience 6037 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LM22B 10

catalog :

6037

quantity :

10 mg (also 50 mg)

price :

160 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Yang T, Massa S, Tran K, Simmons D, Rajadas J, Zeng A, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016;110:343-361 pubmed publisher

product information

brand :

Tocris

master code :

6037

SKU :

6037/10

product name :

LM22B 10

description :

TrkB and TrkC agonist; brain penetrant

target :

Trk Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

485.02

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro . Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.

catalog number base :

6037

product keywords :

LM22B10 trkB trkC agonists agonism neurotrophins neurotrophic brain penetrant Trk Receptors 6037,

extended description :

TrkB and TrkC agonist; brain penetrant

chemical name text :

2,2 ,2 ,2 -[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

formula :

C 27 H 33 ClN 2 O 4

formula text :

C27H33ClN2O4

cas num :

342777-54-2

2020 USD :

153

2021 USD :

160 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage