LM22B 10 | Tocris Bioscience 6037/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LM22B 10

catalog :

6037/10

quantity :

10 mg (also 50 mg)

price :

202 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Wilkens R, Hoffrichter A, Kleinsimlinghaus K, Bohl B, Haag C, Lehmann N, et al. Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death. Cell Death Dis. 2022;13:887 pubmed publisher
Tigaret C, Lin T, Morrell E, Sykes L, Moon A, O Donovan M, et al. Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c. Mol Psychiatry. 2021;: pubmed publisher
Yang T, Massa S, Tran K, Simmons D, Rajadas J, Zeng A, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016;110:343-361 pubmed publisher

image

image 1 :

Cat.No. 6037 - LM22B 10 C27H33ClN2O4 CAS No. 342777-54-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6037

SKU :

6037/10

product name :

LM22B 10

description :

TrkB and TrkC agonist; brain penetrant

target :

Trk Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

485.02

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LM22B 10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro . Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.

product keywords :

LM22B10 trkB trkC agonists agonism neurotrophins neurotrophic brain penetrant Trk Receptors 6037,

extended description :

TrkB and TrkC agonist; brain penetrant

chemical name text :

2,2 ,2 ,2 -[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

formula :

C27H33ClN2O4

formula text :

C27H33ClN2O4

cas num :

342777-54-2

USD :

200

USD 2025 :

202 USD

product details :

TrkB and TrkC agonist; brain penetrant

more info or order :

Tocris Bioscience product webpage