FRAX 597 | Tocris Bioscience 6029 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FRAX 597

catalog :

6029

quantity :

10 mg (also 50 mg)

price :

231 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6029

SKU :

6029/10

product name :

FRAX 597

description :

Potent group I PAK inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

558.1

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 10 M for PAK4). Inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.

catalog number base :

6029

product keywords :

FRAX597 potent group I PAK inhibits inhibitors p21 activated kinase P21-activated Kinases 6029, p21-Activated Kinases, p21-Activated Kinase, PAKs

extended description :

Potent group I PAK inhibitor

chemical name text :

6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one

formula :

C 29 H 28 ClN 7 OS

formula text :

C29H28ClN7OS

cas num :

1286739-19-2

2020 USD :

222

2021 USD :

231 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage