FRAX 597 | Tocris Bioscience 6029/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FRAX 597

catalog :

6029/10

quantity :

10 mg (also 50 mg)

price :

290 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Jahid S, Ortega J, Vuong L, Acquistapace I, Hachey S, Flesher J, et al. Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022;39:110641 pubmed publisher
Ko x159 xe1 nov xe1 T, Dvo x159 xe1 x10d ek L, Grebe x148 ov xe1 D, R xf6 selov xe1 P, Obr A, Ku x17e elov xe1 K. PAK1 and PAK2 in cell metabolism regulation. J Cell Biochem. 2022;123:375-389 pubmed publisher
Hirose S, Tabata Y, Sone K, Takahashi N, Yoshino D, Funamoto K. P21-activated kinase regulates oxygen-dependent migration of vascular endothelial cells in monolayers. Cell Adh Migr. 2021;15:272-284 pubmed publisher

image

image 1 :

Cat.No. 6029 - FRAX 597 C29H28ClN7OS CAS No. 1286739-19-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6029

SKU :

6029/10

product name :

FRAX 597

description :

Potent group I PAK inhibitor

target :

PAK Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

558.1

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FRAX 597 is a potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 10 M for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.

product keywords :

FRAX597 potent group I PAK inhibits inhibitors p21 activated kinase P21-activated Kinases 6029, p21-Activated Kinases, p21-Activated Kinase, PAKs

extended description :

Potent group I PAK inhibitor

chemical name text :

6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one

formula :

C29H28ClN7OS

formula text :

C29H28ClN7OS

cas num :

1286739-19-2

USD :

287

USD 2025 :

290 USD

product details :

Potent group I PAK inhibitor

more info or order :

Tocris Bioscience product webpage