(S)-Crizotinib | Tocris Bioscience 6025/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(S)-Crizotinib

catalog :

6025/10

quantity :

10 mg (also 50 mg)

price :

154 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Wang J, Nagy N, Masucci M. The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization. Oncogene. 2020;39:603-616 pubmed publisher

image

image 1 :

Cat.No. 6025 - (S)-Crizotinib C21H22Cl2FN5O CAS No. 1374356-45-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6025

SKU :

6025/10

product name :

(S)-Crizotinib

description :

MTH1 inhibitor

target :

MTH1 Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

450.34

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( S )-Crizotinib is a potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro . Suppresses tumor growth ~50% in a colon cancer carcinoma xenograft model.

product keywords :

potent MTH1 inhibitors inhibits ras transformation anticancer hydrolases g proteins mutT homologue NUDT1 nucleotide pool homeostasis DNA damage MutT homolog-1 (MTH1) 6025, MTH 1

extended description :

MTH1 inhibitor

chemical name text :

3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

formula :

C21H22Cl2FN5O

formula text :

C21H22Cl2FN5O

cas num :

1374356-45-2

USD :

171

USD 2025 :

154 USD

product details :

MTH1 inhibitor

more info or order :

Tocris Bioscience product webpage