IN 1130 | Tocris Bioscience 6016 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IN 1130

catalog :

6016

quantity :

5 mg

price :

116 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6016

SKU :

6016/5

product name :

IN 1130

description :

Potent and selective inhibitor of TGF- RI

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

420.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of TGF- type I receptor (ALK5). Inhibits Smad-2 phosphorylation (IC50 = 5.3 nM). Exhibits selectivity over a panel of 27 serine/ threonine and tyrosine kinases including P38 . Attenuates TGF /Smad signaling, cell migration, invasion, lung metastasis and increases survival of mice in 4TI in vivo models. Suppresses renal fibrosis in obstructive nephropathy in vivo models.

catalog number base :

6016

product keywords :

IN1130 potent selective inhibitors inhibits TGF- type I receptor ALK5 Smad breast lung metastasis TGF- RI TGF-beta Receptors 6016,

extended description :

Potent and selective inhibitor of TGF- RI

chemical name text :

3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide

formula :

C 25 H 20 N 6 O

formula text :

C25H20N6O

cas num :

868612-83-3

2020 USD :

112

2021 USD :

116 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage