IN 1130 | Tocris Bioscience 6016/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IN 1130

catalog :

6016/5

quantity :

5 mg

price :

147 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6016 - IN 1130 C25H20N6O CAS No. 868612-83-3

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6016

SKU :

6016/5

product name :

IN 1130

description :

Potent and selective inhibitor of TGF- RI

target :

TGF-beta Receptor Inhibitors

unit size :

5 mg

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

420.47

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IN 1130 is a potent and selective inhibitor of TGF- type I receptor (ALK5). Inhibits Smad-2 phosphorylation (IC50 = 5.3 nM). Exhibits selectivity over a panel of 27 serine/ threonine and tyrosine kinases including P38 . Attenuates TGF /Smad signaling, cell migration, invasion, lung metastasis and increases survival of mice in 4TI in vivo models. Suppresses renal fibrosis in obstructive nephropathy in vivo models.

product keywords :

IN1130 potent selective inhibitors inhibits TGF- type I receptor ALK5 Smad breast lung metastasis TGF- RI TGF-beta Receptors 6016,

extended description :

Potent and selective inhibitor of TGF- RI

chemical name text :

3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide

formula :

C 25 H 20 N 6 O

formula text :

C25H20N6O

cas num :

868612-83-3

USD :

145

USD 2025 :

147 USD

product details :

Potent and selective inhibitor of TGF- RI

more info or order :

Tocris Bioscience product webpage