TAPI 2 | Tocris Bioscience 6013/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TAPI 2

catalog :

6013/1

quantity :

1 mg

price :

368 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Maurer D, Adamik J, Santos P, Shi J, Shurin M, Kirkwood J, et al. Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. Cancer Immunol Res. 2020;8:1554-1567 pubmed publisher
Liao T, Chen W, Sun J, Zhang Y, Hu X, Yang S, et al. CXCR4 Accelerates Osteoclastogenesis Induced by Non-Small Cell Lung Carcinoma Cells Through Self-Potentiation and VCAM1 Secretion. Cell Physiol Biochem. 2018;50:1084-1099 pubmed publisher
Prakasam H, Gallo L, Li H, Ruiz W, Hallows K, Apodaca G. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014;25:3798-812 pubmed publisher

product information

brand :

Tocris

catalog number base :

6013

SKU :

6013/1

product name :

TAPI 2

units size :

1 mg

description :

ADAM-17 (TACE) and MMP inhibitor

target :

Synthetic Metalloprotease Inhibitors

category :

Peptides

purity :

95%

observed molecular weight :

415.54

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

TAPI 2 is an ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro . Blocks shedding of TNF- from cell membranes. . This product is typically reconstituted in water.

top caption :

ADAM-17 (TACE) and MMP inhibitor

extended description :

ADAM-17 (TACE) and MMP inhibitor

chemical name text :

N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide

formula :

C19H37N5O5

formula text :

C19H37N5O5

cas num :

689284-12-6

USD :

368 USD

product details :

ADAM-17 (TACE) and MMP inhibitor

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage