TP 064 | Tocris Bioscience 6008/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TP 064

catalog :

6008/10

quantity :

10 mg (also 50 mg)

price :

182 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Lai Y, Li X, Li T, Li X, Nyunoya T, Chen K, et al. Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis. Thorax. 2023;78:383-393 pubmed publisher
Liu L, Lin B, Yin S, Ball L, Delaney J, Long D, et al. Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair. Sci Adv. 2022;8:eadd8928 pubmed publisher
Clemons G, Silva A, Acosta C, Udo M, Tesic V, Rodgers K, et al. Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease. J Cell Physiol. 2022;: pubmed publisher
Wang Y, Person M, Bedford M. Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens. Methods. 2022;200:80-86 pubmed publisher
Lai Y, Li X, Li T, Nyunoya T, Chen K, Kitsios G, et al. Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia. Cell Death Dis. 2021;12:828 pubmed publisher
Zhang Y, de Boer M, van der Wel E, Van Eck M, Hoekstra M. PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo. Biochim Biophys Acta Mol Basis Dis. 2021;1867:166212 pubmed publisher
Genois M, Gagné J, Yasuhara T, Jackson J, Saxena S, Langelier M, et al. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Mol Cell. 2021;81:784-800.e8 pubmed publisher
Zhong X, Yuan X, Xu Y, Yin M, Yan W, Zou S, et al. CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer. Cell Rep. 2018;24:3207-3223 pubmed publisher

product information

brand :

Tocris

catalog number base :

6008

SKU :

6008/10

product name :

TP 064

units size :

10 mg (also 50 mg)

description :

Potent and selective PRMT 4 inhibitor

target :

Protein Arginine Methyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

458.6

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are 10 and 43 nM, respectively). Exhibits 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo . TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo . . To request the negative control for TP 064, please fill out the TP 064N request form on the SGC website. .

top caption :

Potent and selective PRMT 4 inhibitor

extended description :

Potent and selective PRMT 4 inhibitor

chemical name text :

N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide

formula :

C28H34N4O2

formula text :

C28H34N4O2

cas num :

2080306-20-1

USD :

182 USD

product details :

Potent and selective PRMT 4 inhibitor

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage