BAY 598 | Tocris Bioscience 5991 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BAY 598

catalog :

5991

quantity :

25 mg

price :

855 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5991

SKU :

5991/25

product name :

BAY 598

description :

Potent and selective SMYD2 inhibitor

target :

Additional Lysine Methyltransferase Compounds

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

525.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively). Displays 100-fold selectivity for SMYD2 over a panel of 32 other methyltransferases including SMYD3, SUV420H1, and SUV420H2. Enhances apoptotic responses to doxorubicin (Cat. No. 2252) in cancer cell lines. Decreases p53K370me levels in HEK293 cells. Reduces methylation in tumor cells in a mouse xenograft model. . To request the negative control for BAY 598, please fill out the BAY 369 request form on the SGC website.

catalog number base :

5991

product keywords :

BAY598 lysine methyltransferase inhibitors inhibits potent selective SMYD2 SET and MYND domain contain protein 2 Other Lysine Methyltransferases 5991,

extended description :

Potent and selective SMYD2 inhibitor

chemical name text :

N-[(4S)-1-[(Cyanoamino)[[3-(difluoromethoxy)phenyl]imino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide

formula :

C 22 H 20 Cl 2 F 2 N 6 O 3

formula text :

C22H20Cl2F2N6O3

cas num :

1906919-67-2

2020 USD :

855

2021 USD :

855 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage