BAY 598 | Tocris Bioscience 5991/5 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BAY 598

catalog :

5991/5

quantity :

5 mg (also 25 mg)

price :

264 USD

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5991

SKU :

5991/5

product name :

BAY 598

description :

Potent and selective SMYD2 inhibitor

target :

Additional Lysine Methyltransferase Compounds

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

525.34

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively), which displays 100-fold selectivity for SMYD2 over a panel of 32 other methyltransferases including SMYD3, SUV420H1, and SUV420H2. BAY 598 enhances apoptotic responses to doxorubicin (Cat. No. 2252) in cancer cell lines, and decreases p53K370me levels in HEK293 cells. It also reduces methylation in tumor cells in a mouse xenograft model. . To request the negative control for BAY 598, please fill out the BAY 369 request form on the SGC website.

product keywords :

BAY598 lysine methyltransferase inhibitors inhibits potent selective SMYD2 SET and MYND domain contain protein 2 Other Lysine Methyltransferases 5991,

extended description :

Potent and selective SMYD2 inhibitor

chemical name text :

N-[(4S)-1-[(Cyanoamino)[[3-(difluoromethoxy)phenyl]imino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide

formula :

C22H20Cl2F2N6O3

formula text :

C22H20Cl2F2N6O3

cas num :

1906919-67-2

USD :

256

USD 2025 :

264 USD

product details :

Potent and selective SMYD2 inhibitor