BIRB 796 | Tocris Bioscience 5989/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIRB 796

catalog :

5989/10

quantity :

10 mg (also 50 mg)

price :

126 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Singh R, Diwan M, Dastidar S, Najmi A. Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Hum Exp Toxicol. 2018;37:521-531 pubmed publisher

product information

brand :

Tocris

master code :

5989

SKU :

5989/10

rank :

0.0006

product name :

BIRB 796

description :

High affinity and selective p38 kinase inhibitor

target :

p38 Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNF production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2 2 and c-Raf-1 (IC50 values are 98 nM and 1.4 M, respectively). BIRB 796 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs. Cell permeable.

extended description :

High affinity and selective p38 kinase inhibitor

chemical name text :

N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N -[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea

formula :

C 31 H 37 N 5 O 3

formula text :

C31H37N5O3

cas num :

285983-48-4

USD :

126 USD

product details :

High affinity and selective p38 kinase inhibitor

alt names :

Doramapimod

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage