NAV 2729 | Tocris Bioscience 5986 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NAV 2729

catalog :

5986

quantity :

10 mg (also 50 mg)

price :

198 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Ernst D, Williams B, Wang X, Yoon N, Kim K, Chiu J, et al. Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1. Blood Cancer J. 2019;9:6 pubmed publisher
Finicle B, Ramirez M, Liu G, Selwan E, McCracken A, Yu J, et al. Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. J Cell Sci. 2018;131: pubmed publisher

product information

brand :

Tocris

master code :

5986

SKU :

5986/10

product name :

NAV 2729

description :

Selective ARF6 inhibitor

target :

ARF GTPase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

456.88

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective ARF6 inhibitor (IC50 = 1.0 M). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.

catalog number base :

5986

product keywords :

NAV2729 small G proteins G q GTPases inhibitors inhibits selective ARF6 GNAQ Arf 5986, ARF, ADP ribosylation factor, GTP ase,

extended description :

Selective ARF6 inhibitor

chemical name text :

3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

formula :

C 25 H 17 ClN 4 O 3

formula text :

C25H17ClN4O3

cas num :

419547-11-8

2020 USD :

188

2021 USD :

198 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage