NAV 2729 | Tocris Bioscience 5986/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NAV 2729

catalog :

5986/10

quantity :

10 mg (also 50 mg)

price :

230 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Ernst D, Williams B, Wang X, Yoon N, Kim K, Chiu J, et al. Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1. Blood Cancer J. 2019;9:6 pubmed publisher
Finicle B, Ramirez M, Liu G, Selwan E, McCracken A, Yu J, et al. Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. J Cell Sci. 2018;131: pubmed publisher

image

image 1 :

Cat.No. 5986 - NAV 2729 C25H17ClN4O3 CAS No. 419547-11-8

product information

brand :

Tocris

master code :

5986

SKU :

5986/10

rank :

0.0006

product name :

NAV 2729

description :

Selective ARF6 inhibitor

target :

ARF GTPase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NAV 2729 is a selective ARF6 inhibitor (IC50 = 1.0 M). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.

extended description :

Selective ARF6 inhibitor

chemical name text :

3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

formula :

C 25 H 17 ClN 4 O 3

formula text :

C25H17ClN4O3

cas num :

419547-11-8

USD :

230 USD

product details :

Selective ARF6 inhibitor

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage