TMI 1 | Tocris Bioscience 5960 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TMI 1

catalog :

5960

quantity :

10 mg (also 50 mg)

price :

265 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5960

SKU :

5960/10

product name :

TMI 1

description :

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

target :

Synthetic Metalloprotease Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

398.49

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ADAM17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF- production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro . Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.

catalog number base :

5960

product keywords :

TMI1 Adam 17 TACE MMP inhibitors inhibits tumor necrosis factor- TNF- converting enzyme rheumatoid arthritis cancer stem cells anticancer cytotoxic orally bioavailable matrixins matrix metalloproteinases proteinases proteases disintegrin meta Matrix Metalloprotease Cancer Stem Cells ADAMs 5960,

extended description :

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

chemical name text :

(3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide

formula :

C 17 H 22 N 2 O 5 S 2

formula text :

C17H22N2O5S2

cas num :

287403-39-8

2020 USD :

257

2021 USD :

265 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage