TMI 1 | Tocris Bioscience 5960/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TMI 1

catalog :

5960/10

quantity :

10 mg (also 50 mg)

price :

307 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5960

SKU :

5960/10

rank :

0.0006

product name :

TMI 1

description :

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

target :

Synthetic Metalloprotease Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TMI 1 is an ADAM17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF- production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro . Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.

extended description :

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

chemical name text :

(3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide

formula :

C 17 H 22 N 2 O 5 S 2

formula text :

C17H22N2O5S2

cas num :

287403-39-8

USD :

307 USD

product details :

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage