chemical

C3

5957

10 mg (also 50 mg)

199 USD

5957

5957/10

C3

Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor

Additional Isomerase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

382.54

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Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 90 and 900 nM for rat and human mPGES-1, respectively). Displays selectivity for mPGES-1 over COX-1, COX-2, PGIS, hPGDS and iPGDS (% inhibition values are 15, 18, 0, 0 and 60 % inhibition at 50 M, respectively). Reduces PGE2 production in vitro and in a localized inflammation animal model. Elevates CD80 expression by tumor associated phagocytes in vitro . Also decreases vascular contractility, in ex vivo human vessels.

5957

compound 3 selective microsomal prostaglandin E synthase 1 inhibitors inhibits mPGES-1 PGES PGE2 Other Synthases/Synthetases 5957,

Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor

N-Cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-4-piperidinecarboxamide

C 23 H 34 N 4 O

C23H34N4O

1268709-57-4

195

199 USD

Store at -20°C