chemical

NF 1819

5956

10 mg

185 USD

5956

5956/10

NF 1819

Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant

Monoacylglycerol Lipase Inhibitors

Small Molecules

10 mg

98%

463.46

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

Potent and selective irreversible MAGL inhibitor (IC50 values are 0.25 and 7.4 nM at rMAGL and hMAGL, respectively). Exhibits 389-fold selectivity over hFAAH and exhibits minimal binding at CB receptors (IC50 10 M). Alleviates symptoms in a MS in vivo model. Exhibits analgesic effects in an acute inflammatory pain model in vivo . Ameliorates neuropathic hypersensitivity induced by oxaliplatin (Cat. No. 2623). Displays high membrane permeability and brain penetrant.

5956

NF1819 Potent selective irreversible MAGL inhibitors inhibits MS multiple sclerosis analgesics neuropathic hypersensitivity membrane permeable brain penetrant MAGL 5956, MAGL

Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant

(3R,4S)-rel-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H)-1,2,4-triazol-1-carbonyl)-4-piperidinyl]-2-azetidinone

C 24 H 22 FN 5 O 4

C24H22FN5O4

1881244-28-5

179

185 USD

Store at -20°C