PDD 00017273 | Tocris Bioscience 5952 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PDD 00017273

catalog :

5952

quantity :

1 mg (also 10 mg)

price :

125 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Houl J, Ye Z, Brosey C, Balapiti Modarage L, Namjoshi S, Bacolla A, et al. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019;10:5654 pubmed publisher
Keuss M, Hjerpe R, Hsia O, Gourlay R, Burchmore R, Trost M, et al. Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death. EMBO J. 2019;38: pubmed publisher
Moore S, Berger N, Luijsterburg M, Piett C, Stanley F, Schräder C, et al. The CHD6 chromatin remodeler is an oxidative DNA damage response factor. Nat Commun. 2019;10:241 pubmed publisher
Hanzlikova H, Kalasová I, Demin A, Pennicott L, Cihlarova Z, Caldecott K. The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication. Mol Cell. 2018;71:319-331.e3 pubmed publisher

product information

brand :

Tocris

master code :

5952

SKU :

5952/1

product name :

PDD 00017273

description :

Potent and selective PARG inhibitor; cell permeable

target :

Hydrolase Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

98%

observed molecular weight :

514.62

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits 350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.

catalog number base :

5952

product keywords :

PDD00017273 potent selective PARG poly-(ADP-ribose)-glycohydrolase inhibits inhibitors DNA repair Poly(ADP)-ribose Glycohydrolase 5952,

extended description :

Potent and selective PARG inhibitor; cell permeable

chemical name text :

1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide

formula :

C 23 H 26 N 6 O 4 S 2

formula text :

C23H26N6O4S2

cas num :

1945950-21-9

2020 USD :

119

2021 USD :

125 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage