PF 05089771 | Tocris Bioscience 5931 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 05089771

catalog :

5931

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Cheng R, Feng Y, Liu D, Wang Z, Zhang J, Chen L, et al. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics. 2019;9:4287-4307 pubmed publisher

product information

brand :

Tocris

master code :

5931

SKU :

5931/10

product name :

PF 05089771

description :

Potent and selective Nav1.7 channel blocker

target :

Voltage-gated Sodium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

672.56

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective Nav1.7 channel blocker (IC50 = 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively). Exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 M for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Also exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters. Blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro .

catalog number base :

5931

product keywords :

PF05089771 potent selective Nav1.7 sodium channels neuropathic pain Voltage-gated Sodium Channels 5931,

extended description :

Potent and selective Nav1.7 channel blocker

chemical name text :

4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate

formula :

C 18 H 12 Cl 2 FN 5 O 3 S 2 .C 7 H 8 O 3 S

formula text :

C18H12Cl2FN5O3S2.C7H8O3S

cas num :

1430806-04-4

2020 USD :

166

2021 USD :

173 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage