PF 05089771 | Tocris Bioscience 5931/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 05089771

catalog :

5931/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Fu Y, Sun L, Zhu F, Xia W, Wen T, Xia R, et al. Ectopic expression of Nav1.7 in spinal dorsal horn neurons induced by NGF contributes to neuropathic pain in a mouse spinal cord injury model. Front Mol Neurosci. 2023;16:1091096 pubmed publisher
Alich T, R xf6 derer P, Szalontai B, Golcuk K, Tariq S, Peitz M, et al. Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings. Front Cell Neurosci. 2022;16:1039957 pubmed publisher
Espino C, Lewis C, Ortiz S, Dalal M, Garlapalli S, Wells K, et al. NaV1.1 is essential for proprioceptive signaling and motor behaviors. elife. 2022;11: pubmed publisher
MacDonald D, Sikandar S, Weiss J, Pyrski M, Luiz A, Millet Q, et al. A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7. Neuron. 2021;109:1497-1512.e6 pubmed publisher
Griffith T, Docter T, Lumpkin E. Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons. J Neurosci. 2019;39:7086-7101 pubmed publisher
Cheng R, Feng Y, Liu D, Wang Z, Zhang J, Chen L, et al. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics. 2019;9:4287-4307 pubmed publisher

image

image 1 :

Cat.No. 5931 - PF 05089771 C18H12Cl2FN5O3S2.C7H8O3S CAS No. 1430806-04-4

product information

brand :

Tocris

MasterCode :

5931

SKU :

5931/10

product name :

PF 05089771

target :

Voltage-gated Sodium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

672.56

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 05089771 is a potent and selective Nav1.7 channel blocker (IC50 = 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively). Exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 M for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Also exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters. Blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro .

extended description :

Potent and selective Nav1.7 channel blocker

chemical name text :

4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate

formula :

C 18 H 12 Cl 2 FN 5 O 3 S 2 .C 7 H 8 O 3 S

formula text :

C18H12Cl2FN5O3S2.C7H8O3S

cas num :

1430806-04-4

USD :

219 USD

product details :

Potent and selective Nav1.7 channel blocker

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage