NS 383 | Tocris Bioscience 5927/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NS 383

catalog :

5927/10

quantity :

10 mg (also 50 mg)

price :

141 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 5927 - NS 383 C19H19N3O2 CAS No. 309711-59-9

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5927

SKU :

5927/10

product name :

NS 383

description :

ASIC blocker; active in vivo

target :

Acid-sensing Ion Channel Blockers

unit size :

10 mg (also 50 mg)

category :

Small Molecules

storage :

Store at -20°C

observed molecular weight :

321.37

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 M and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 M at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

product keywords :

NS383 ASIC blockers acid-sensing ion channels inflammatory pain ASIC Voltage-gated Sodium Channels 5927,

extended description :

ASIC blocker; active in vivo

chemical name text :

8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime

formula :

C19H19N3O2

formula text :

C19H19N3O2

cas num :

309711-59-9

USD :

156

USD 2025 :

141 USD

product details :

ASIC blocker; active in vivo

more info or order :

Tocris Bioscience product webpage