ER 819762 | Tocris Bioscience 5924 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ER 819762

catalog :

5924

quantity :

5 mg

price :

220 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5924

SKU :

5924/5

product name :

ER 819762

description :

Potent EP4 receptor antagonist; orally bioavailable

target :

Prostanoid Receptor Antagonists

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

489.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent EP4 receptor antagonist (IC50 = 59 nM). Suppresses EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. Inhibits Th1 and Th17 cytokine production, suppresses collagen- and GPI-induced arthritis in mice. Attenuates CFA-induced inflammatory pain in rats. Analgesic. Orally bioavailable.

catalog number base :

5924

product keywords :

ER819762 potent EP4 receptors antagonists prostanoids PGE2 prostaglandins high affinity orally active orally bioavailable analgesics arthritis inflammatory pain inflammation Prostanoid Receptors 5924,

extended description :

Potent EP4 receptor antagonist; orally bioavailable

chemical name text :

(10S)-1 -[(3,5-Dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methylspiro[1H-imidazo[1,5-b][2]benzazepine-1,4 -piperidin]-3(2H)-one

formula :

C 30 H 39 N 3 O 3

formula text :

C30H39N3O3

cas num :

1155773-15-1

2020 USD :

220

2021 USD :

220 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage