chemical

PF 04449613

5915/10

10 mg

317 USD

5915

5915/10

PF 04449613

Potent PDE9 inhibitor; brain penetrant

Phosphodiesterase Inhibitors

10 mg

Small Molecules

98%

Store at -20°C

395.45

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PF 04449613 is a potent PDE9 inhibitor (IC50 = 22 nM). PF 4449613 shows more than 1000-fold selectivity for PDE9A over most of 79 other non-PDE targets investigated, except for cytochrome P450 2C19 (IC50 = 1600 nM), dopamine transporter (Ki = 110 nM), -opioid receptor (Ki =3500 nM), and sodium channel binding site 2 (Ki =470 nM). PF 04449613 reduces body fat in mice with diet-induced obesity, stimulating mitochondrial activity in brown and white fat, and improving cardiometabolic syndrome symptoms. Brain penetrant. PF 04449613 increases synaptic calcium activity and learning-dependent synaptic plasticity in mice.

PF04449613 PF9613 phosphodiesterases PDE A inhibitors inhibits potent Schizophrenia Alzheimer's disease brain penetrant PF 9613 Phosphodiesterases 5915,

Potent PDE9 inhibitor; brain penetrant

1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one

C21H25N5O3

C21H25N5O3

1236858-52-8

307

317 USD

Potent PDE9 inhibitor; brain penetrant

PF 9613