AM 0902 | Tocris Bioscience 5914/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AM 0902

catalog :

5914/10

quantity :

10 mg (also 50 mg)

price :

163 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Silverman H, Tynan A, Hepler T, Chang E, Gunasekaran M, Li J, et al. Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses. Mol Med. 2023;29:4 pubmed publisher
Vasavda C, Xu R, Liew J, Kothari R, Dhindsa R, Semenza E, et al. Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv. 2022;8:eabo5633 pubmed publisher
Hernández Morales M, Shang T, Chen J, Han V, Liu C. Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels. Cell Rep. 2020;30:3250-3260.e7 pubmed publisher
Huang Y, Chen S, Chen H, Pan H. Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain. J Neurochem. 2019;149:381-398 pubmed publisher

image

image 1 :

Cat.No. 5914 - AM 0902 C17H15ClN6O2 CAS No. 1883711-97-4

product information

brand :

Tocris

MasterCode :

5914

SKU :

5914/10

product name :

AM 0902

target :

TRPA1 Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

370.79

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AM 0902 is a potent and selective TRPA1 antagonist (IC50 = 0.02 M for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.

extended description :

Potent and selective TRPA1 antagonist

chemical name text :

1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one

formula :

C 17 H 15 ClN 6 O 2

formula text :

C17H15ClN6O2

cas num :

1883711-97-4

USD :

163 USD

product details :

Potent and selective TRPA1 antagonist

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage