VX 680 | Tocris Bioscience 5907 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VX 680

catalog :

5907

quantity :

50 mg

price :

112 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5907

SKU :

5907/50

product name :

VX 680

description :

High affinity and selective Aurora kinase inhibitor

target :

Aurora Kinase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

464.59

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity and selective Aurora kinase inhibitor (Ki values are 0.6, 5 and 18 nM for Aurora A, Aurora C and Aurora B, respectively). Also exhibits affinity for FLT-3 and Abl. Exhibits selectivity for Aurora kinase over 190 other protein kinases. Inhibits proliferation and induces apoptosis in a number of cancer cell lines in vitro . Reduces tumor size in leukemia and colon cancer cell xenografts in mice.

catalog number base :

5907

product keywords :

VX680 MK0457 high affinity selective aurora kinases inhibitors inhibits AurA AurB AurC MK 0457 Tozasertib Aurora Kinases 5907,

extended description :

High affinity and selective Aurora kinase inhibitor

chemical name text :

N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide

formula :

C 23 H 28 N 8 OS

formula text :

C23H28N8OS

cas num :

639089-54-6

2020 USD :

108

2021 USD :

112 USD

alt names :

MK 0457, Tozasertib

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage