Cilengitide | Tocris Bioscience 5870 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cilengitide

catalog :

5870

quantity :

10 mg

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Filla M, Faralli J, Desikan H, Peotter J, Wannow A, Peters D. Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner. Invest Ophthalmol Vis Sci. 2019;60:3897-3913 pubmed publisher
Yoon Lee J, Chung J, Hwa Kim K, Hyun An S, Yi J, Ae Kwon K, et al. Extracorporeal shock waves protect cardiomyocytes from doxorubicin-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis. Sci Rep. 2019;9:12149 pubmed publisher
Albarrán Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, et al. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018;215:2655-2672 pubmed publisher

product information

brand :

Tocris

master code :

5870

SKU :

5870/10

product name :

Cilengitide

description :

Potent and selective inhibitor of integrins v 3 and v 5

target :

Integrin Receptor Inhibitors

category :

Peptides

unit size :

10 mg

observed molecular weight :

588.66

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Potent and selective inhibitor of integrins v 3 and v 5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

catalog number base :

5870

product keywords :

Potent selective inhibitors inhibits integrin v 3 v 5 alphavbeta3 alphavbeta5 EMD121974 Integrins Cell Adhesion Molecules 5870,

extended description :

Potent and selective inhibitor of integrins v 3 and v 5

formula :

C 27 H 40 N 8 O 7

formula text :

C27H40N8O7

cas num :

188968-51-6

2020 USD :

203

2021 USD :

214 USD

alt names :

EMD121974

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage