chemical

Tolcapone

5864/10

10 mg (also 50 mg)

109 USD

5864

5864/10

Tolcapone

COMT inhibitor; also inhibits transthyretin aggregation

Catechol O-Methyltransferase (COMT) Inhibitors

10 mg (also 50 mg)

Small Molecules

99%

Store at +4°C

273.24

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Tolcapone is a COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro . Stabilizes TTR in mice and humans in vivo . Orally bioavailable.

catechol O-methyl transferase inhibitors inhibits COMT orally bioavailable high affinity TTR binding transthyretin aggregation Ro40-7592 Tasmar Ro 40-7592 Catechol O-Methyltransferase 5864, Breast Cancer, Schizophrenia, Parkinsons, Catechol O-Methyltransferase, Catechol O Methyltransferase, O-methylation catecholamines, catecholamine, dopamine, epinephrine, norepinephrine, adrenalin, noradrenalin, L-DOPA, alpha-methyl DOPA, isoproterenol

COMT inhibitor; also inhibits transthyretin aggregation

(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone

C14H11NO5

C14H11NO5

134308-13-7

107

109 USD

COMT inhibitor; also inhibits transthyretin aggregation

Tasmar,Ro 40-7592