AX 15836 | Tocris Bioscience 5843 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AX 15836

catalog :

5843

quantity :

10 mg

price :

328 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5843

SKU :

5843/10

product name :

AX 15836

description :

Potent and selective ERK5 inhibitor

target :

ERK Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

648.78

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits 1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro , as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.

catalog number base :

5843

product keywords :

AX15836 potent selective ERK5 inhibitors inhibits vomocytosis XMD17-109 ERK 5843,

extended description :

Potent and selective ERK5 inhibitor

chemical name text :

5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

formula :

C 32 H 4 0N 8 O 5 S

formula text :

C32H40N8O5S

cas num :

2035509-96-5

2020 USD :

318

2021 USD :

328 USD

alt names :

XMD17-109

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage