AX 15836 | Tocris Bioscience 5843/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AX 15836

catalog :

5843/10

quantity :

10 mg

price :

403 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Martínez Fábregas J, Wang L, Pohler E, Cozzani A, Wilmes S, Kazemian M, et al. CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci. Cell Rep. 2020;33:108545 pubmed publisher

image

image 1 :

Cat.No. 5843 - AX 15836 C32H40N8O5S CAS No. 2035509-96-5

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5843

SKU :

5843/10

product name :

AX 15836

description :

Potent and selective ERK5 inhibitor

target :

ERK Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

648.78

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AX 15836 is a potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits 1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro , as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.

product keywords :

AX15836 potent selective ERK5 inhibitors inhibits vomocytosis ERK 5843, extracellular signal-regulated kinase, inhibitor, inhibition, ERK inhibition

extended description :

Potent and selective ERK5 inhibitor

chemical name text :

5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

formula :

C32H40N8O5S

formula text :

C32H40N8O5S

cas num :

2035509-96-5

USD :

399

USD 2025 :

403 USD

product details :

Potent and selective ERK5 inhibitor

more info or order :

Tocris Bioscience product webpage