CBR 5884 | Tocris Bioscience 5836 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CBR 5884

catalog :

5836

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Sen N, Cross A, Lorenzi P, Khan J, Gryder B, Kim S, et al. EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog. 2018;57:1342-1357 pubmed publisher
Nigdelioglu R, Hamanaka R, Meliton A, O LEARY E, Witt L, Cho T, et al. Transforming Growth Factor (TGF)-? Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem. 2016;291:27239-27251 pubmed publisher

product information

brand :

Tocris

master code :

5836

SKU :

5836/10

product name :

CBR 5884

description :

Phosphoglycerate dehydrogenase (PHGDH) inhibitor

target :

Dehydrogenase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

336.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 M). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

catalog number base :

5836

product keywords :

CBR5884 PHGDH 3-phosphoglycerate dehydrogenases inhibitors inhibits serine synthesis cancer Other Dehydrogenases 5836,

extended description :

Phosphoglycerate dehydrogenase (PHGDH) inhibitor

chemical name text :

Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate

formula :

C 14 H 12 N 2 O 4 S 2

formula text :

C14H12N2O4S2

cas num :

681159-27-3

2020 USD :

164

2021 USD :

169 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage