SAR 7334 | Tocris Bioscience 5831/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SAR 7334

catalog :

5831/5

quantity :

5 mg

price :

366 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Waclawikov xe1 B, Bullock A, Schwalbe M, Aranzamendi C, Nelemans S, van Dijk G, et al. Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS Biol. 2021;19:e3001070 pubmed publisher
Golosova D, Palygin O, Bohovyk R, Klemens C, Levchenko V, Spires D, et al. Role of opioid signaling in kidney damage during the development of salt-induced hypertension. Life Sci Alliance. 2020;3: pubmed publisher
Fernandez M, Pettibone H, Bogart J, Roell C, Davey C, Pranevicius A, et al. Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment. Curr Biol. 2020;30:2225-2237.e5 pubmed publisher
Tan Y, Kwan H, Yao X, Leung L. The activity of transient receptor potential channel C-6 modulates the differentiation of fat cells. FASEB J. 2019;33:6526-6538 pubmed publisher

image

image 1 :

Cat.No. 5831 - SAR 7334 C21H22ClN3O.2HCl CAS No. 1333207-63-8

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5831

SKU :

5831/5

product name :

SAR 7334

description :

Potent TRPC6 inhibitor

target :

TRPC Channel Blockers

unit size :

5 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

440.79

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SAR 7334 is a potent TRPC6 inhibitor (IC50 values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca2+ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.

product keywords :

SAR7334 potent transient receptor potential canonical channel TRPC6 inhibitors inhibits orally bioavailable hypoxic pulmonary vasoconstriction hpv TRPC 5831,

extended description :

Potent TRPC6 inhibitor

chemical name text :

4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride

formula :

C21H22ClN3O.2HCl

formula text :

C21H22ClN3O.2HCl

cas num :

1333207-63-8

USD :

351

USD 2025 :

366 USD

product details :

Potent TRPC6 inhibitor

more info or order :

Tocris Bioscience product webpage