NVP BSK 805 | Tocris Bioscience 5818 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NVP BSK 805

catalog :

5818

quantity :

10 mg (also 50 mg)

price :

205 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5818

SKU :

5818/10

product name :

NVP BSK 805

description :

Potent JAK2 inhibitor; orally bioavailable

target :

JAK Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

599.94

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent JAK2 inhibitor (IC50 = 0.48 nM). Exhibits 20-fold selectivity for JAK2 over TYK2, JAK3 and JAK1 (IC50 values are 10.8, 18.7 and 31.6 nM, respectively). Inhibits proliferation and induces apoptosis of JAK2V617F-bearing acute myeloid leukemia cells in vitro and in vivo . Also inhibits erythropoietin-induced polycythemia. Orally bioavailable.

catalog number base :

5818

product keywords :

NVPBSK805 JAK2 inhibitors inhibits potent orally bioavailable AML acute myeloid leukemia polycythemia JAK Kinase 5818,

extended description :

Potent JAK2 inhibitor; orally bioavailable

chemical name text :

8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline trihydrochloride

formula :

C 27 H 28 F 2 N 6 O.3HCl

formula text :

C27H28F2N6O.3HCl

2020 USD :

205

2021 USD :

205 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage