MP A08 | Tocris Bioscience 5803 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MP A08

catalog :

5803

quantity :

10 mg (also 50 mg)

price :

168 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5803

SKU :

5803/10

product name :

MP A08

description :

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

target :

Sphingosine Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

519.64

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 M, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro . Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

catalog number base :

5803

product keywords :

MPA08 Selective ATP competitive sphingosine kinase 1 and 2 SphK sk1 sk2 cell permeable anticancer apoptosis apoptotic NSC122314 NSC 122314 Sphingosine Kinase 5803,

extended description :

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

chemical name text :

4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide

formula :

C 27 H 25 N 3 O 4 S 2

formula text :

C27H25N3O4S2

cas num :

219832-49-2

2020 USD :

164

2021 USD :

168 USD

alt names :

NSC 122314

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage