CHMFL-FLT3-122 | Tocris Bioscience 5800 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CHMFL-FLT3-122

catalog :

5800

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5800

SKU :

5800/10

product name :

CHMFL-FLT3-122

description :

Potent and selective FLT3 inhibitor

target :

Flt-3 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

471.55

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective FLT3 inhibitor (IC50 = 40 nM). Exhibits 10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro . Induces apoptosis by arresting cell cycle in G0/G1 phase in vitro . Suppresses tumor growth in an AML xenograft model. Modestly orally bioavailable.

catalog number base :

5800

product keywords :

Potent selective FLT inhibitors inhibits AML acute myeloid leukemia cell cycle FLT3 Cell Cycle Inhibitors Apoptosis Inducers 5800,

extended description :

Potent and selective FLT3 inhibitor

chemical name text :

1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone

formula :

C 26 H 29 N 7 O 2

formula text :

C26H29N7O2

cas num :

1839150-56-9

2020 USD :

216

2021 USD :

216 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage