A 425619 | Tocris Bioscience 5781 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 425619

catalog :

5781

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Chakrabarti S, Pattison L, Singhal K, Hockley J, Callejo G, Smith E. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. Neuropharmacology. 2018;143:49-62 pubmed publisher

product information

brand :

Tocris

master code :

5781

SKU :

5781/10

product name :

A 425619

description :

Potent TRPV1 antagonist

target :

TRPV Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

345.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent TRPV1 antagonist (IC50 = 3-9 nM). Blocks capsaicin-evoked currents in rat DRG neurons and inhibits TRPV1-activation by anandamide (Cat. No. 1339) and N -arachidonoyl-dopamine. Reduces pain in inflammatory, postoperative and osteoarthritic in vivo pain models.

catalog number base :

5781

product keywords :

A425619 TRPV1 antagonists antagonism transient receptor potential channels vanilloids pain nociception capsaicin TRPV 5781,

extended description :

Potent TRPV1 antagonist

chemical name text :

N-5-Isoquinolinyl-N -[[(4-(trifluoromethyl)phenyl]methyl]urea

formula :

C 18 H 14 F 3 N 3 O

formula text :

C18H14F3N3O

cas num :

581809-67-8

2020 USD :

201

2021 USD :

210 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage