product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
MRT 68921 dihydrochloride
catalog :
5780/5
quantity :
5 mg (also 25 mg)
price :
135 USD
more info or order :
citations: 6
Reference
Wen J, Zellner A, Braun N, Bajaj T, Gassen N, Peitz M, et al. Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity. Transl Psychiatry. 2023;13:143 pubmed publisher
Gómez Sintes R, Xin Q, Jimenez Loygorri J, McCabe M, Díaz A, Garner T, et al. Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration. Nat Commun. 2022;13:4220 pubmed publisher
Parashar S, Chidambaram R, Chen S, Liem C, Griffis E, Lambert G, et al. Endoplasmic reticulum tubules limit the size of misfolded protein condensates. elife. 2021;10: pubmed publisher
Lazki Hagenbach P, Ali H, Sagi Eisenberg R. Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells. Cells. 2021;10: pubmed publisher
Rosignol I, Villarejo Zori B, Terešak P, Sierra Filardi E, Pereiro X, Rodr xed guez Muela N, et al. The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models. Int J Mol Sci. 2020;21: pubmed publisher
Bork T, Liang W, Yamahara K, Lee P, Tian Z, Liu S, et al. Podocytes maintain high basal levels of autophagy independent of mtor signaling. Autophagy. 2020;16:1932-1948 pubmed publisher
image
image 1 :
Tocris Bioscience 5780/5 image 1
Cat.No. 5780 - MRT 68921 dihydrochloride C25H34N6O.2HCl
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
5780
SKU :
5780/5
product name :
MRT 68921 dihydrochloride
description :
ULK inhibitor
target :
Other Kinase Inhibitors
unit size :
5 mg (also 25 mg)
category :
Small Molecules
purity :
98%
storage :
Desiccate at RT
observed molecular weight :
507.5
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.
product keywords :
MRT68921 dihydrochloride ULK1 2 inhibitors inhibits autophagy potent Other Kinases Autophagy 5780,
extended description :
ULK inhibitor
chemical name text :
N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
formula :
C25H34N6O.2HCl
formula text :
C25H34N6O.2HCl
cas num :
2080306-21-2
USD :
133
USD 2025 :
135 USD
product details :
ULK inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK